OR1L6

Across TCGA pan-cancer cohorts, OR1L6 RNA is linked to patient survival in 7 of 34 cancer types, making it the most broadly survival-associated OR1L6 data layer compared with 3 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher OR1L6 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated OR1L6 expression acts as an unfavorable survival marker, although some lineages such as SCLC show a favorable association.

UCEC, THCA, and UVM are the cancer types where OR1L6 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	II,III,IV	0.686	0.832	.011	54	view →
THCA	DFS	Tertile	II,III,IV	0.623	0.933	.001	21	view →
UVM	DFS	Tertile	All	0.247	0.617	.038	18	view →
OV	DFS	Tertile	IV	0.298	0.499	.023	18	view →
SCLC	OS	Tertile	All	0.859	0.297	.019	9	view →
KIRP	OS	Tertile	II,III,IV	0.216	0.771	.049	9	view →
LIHC	DFS	Tertile	II,III,IV	0.130	0.430	.035	9	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

OR1L6–UCEC (DFS)

Open the UCEC breakdown →