OR1L3

Across TCGA patient cohorts, OR1L3 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR1L3-associated genes across cancer lineages are ASNS, Caspase-7-cleavedD198, and Caspase-8. Each is linked with OR1L3 in more than 2 cancer types. Because this analysis shows association rather than direction, both OR1L3-to-partner and partner-to-OR1L3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by OR1L3-low versus OR1L3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR1L3→partner) and Y-score (partner→OR1L3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.591	+2.115	<.001	.019	3	3
UCEC	Caspase-7-cleavedD198 →	+0.644	+3.341	.012	.005	3	2
UCEC	Caspase-8 →	-0.217	-3.432	.048	.005	3	2
SKCM	Bid →	+0.228	+2.000	.002	.031	3	2
UCEC	ACC1 →	+0.334	+2.115	.035	.019	3	1
UCEC	mTOR_pS2448 →	-0.130	-2.986	.046	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

ASNS by OR1L3 expression — UCEC

Explore this box plot interactively →