OR1K1

Across TCGA patient cohorts, OR1K1 mutation is significantly associated with the RNA expression of many other genes, with 1,194 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR1K1-associated genes across cancer lineages are RN7SKP181, OR51T1, and OR2T29. Each is linked with OR1K1 in more than 2 cancer types. Because this analysis shows association rather than direction, both OR1K1-to-partner and partner-to-OR1K1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP181 grouped by OR1K1-low versus OR1K1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR1K1→partner) and Y-score (partner→OR1K1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RN7SKP181 →	+0.580	+5.087	<.001	.002	3	3
COAD	OR51T1 →	+0.235	+4.225	<.001	.007	3	3
LUAD	OR2T29 →	+0.025	+4.912	<.001	.003	3	2
LUAD	RNU6-23P →	+0.169	+4.197	<.001	.009	3	2
LUAD	RPS11P1 →	+0.078	+3.656	.003	.006	3	2
LUAD	OR4C45 →	+0.042	+4.739	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,194 associations by consensus.

RN7SKP181 by OR1K1 expression — COAD

Explore this box plot interactively →