OR1J4

Across TCGA patient cohorts, OR1J4 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR1J4-associated genes across cancer lineages are MEK1, CDK1, and NDRG1_pT346. Each is linked with OR1J4 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR1J4-to-partner and partner-to-OR1J4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by OR1J4-low versus OR1J4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR1J4→partner) and Y-score (partner→OR1J4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.442	+3.321	.021	.010	3	1
UCEC	CDK1 →	+0.202	+3.000	.010	.036	3	1
SKCM	NDRG1_pT346 →	-0.669	-2.321	.013	.006	3	1
SKCM	p90 RSK →	+0.206	+1.807	.017	.026	3	1
SKCM	PCNA →	+0.174	+3.459	.028	.005	3	1
SKCM	AMPK_pT172 →	+0.300	+3.169	.026	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

MEK1 by OR1J4 expression — UCEC

Explore this box plot interactively →