OR1E2

Across TCGA patient cohorts, OR1E2 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR1E2-associated genes across cancer lineages are eEF2, A-Raf_pS299, and ERK2. Each is linked with OR1E2 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR1E2-to-partner and partner-to-OR1E2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by OR1E2-low versus OR1E2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR1E2→partner) and Y-score (partner→OR1E2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.331	+2.222	.029	.011	3	1
UCEC	A-Raf_pS299 →	-0.117	-2.906	.021	.001	3	1
UCEC	ERK2 →	+0.284	+2.584	<.001	.010	3	1
UCEC	FOXO3a_pS318_S321 →	-0.131	-2.222	.013	.011	3	1
UCEC	IGFBP2 →	-0.584	-1.700	.034	.044	3	1
UCEC	JNK_pT183_Y185 →	-0.237	-2.893	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

eEF2 by OR1E2 expression — UCEC

Explore this box plot interactively →