OR1E1

Across TCGA patient cohorts, OR1E1 mutation is significantly associated with the RNA expression of many other genes, with 318 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR1E1-associated genes across cancer lineages are RNA5SP412, LINC01858, and RNA5SP413. Each is linked with OR1E1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR1E1-to-partner and partner-to-OR1E1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP412 grouped by OR1E1-low versus OR1E1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR1E1→partner) and Y-score (partner→OR1E1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP412 →	+1.118	+3.230	<.001	<.001	3	2
CESC	LINC01858 →	+0.020	+3.760	.001	.007	3	2
UCEC	RNA5SP413 →	+2.023	+3.084	<.001	<.001	3	2
CESC	RNA5SP248 →	+0.283	+4.345	<.001	.002	3	2
SKCM	SNORD114-6 →	+0.151	+4.906	<.001	.001	3	2
SKCM	SPATA17-AS1 →	+0.081	+2.577	.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 318 associations by consensus.

RNA5SP412 by OR1E1 expression — UCEC

Explore this box plot interactively →