OR1E1

Across TCGA patient cohorts, OR1E1 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR1E1-associated genes across cancer lineages are ERK2, PI3K-p85, and VHL. Each is linked with OR1E1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR1E1-to-partner and partner-to-OR1E1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by OR1E1-low versus OR1E1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR1E1→partner) and Y-score (partner→OR1E1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ERK2 →	+0.250	+3.169	.029	.019	3	1
UCEC	PI3K-p85 →	-0.356	-3.000	.003	.037	3	1
UCEC	VHL →	-0.854	-3.000	.029	.037	3	1
UCEC	Notch1 →	+0.346	+3.000	<.001	.037	1	2
UCEC	Caspase-8 →	-0.373	-3.000	.010	.036	2	1
SKCM	FoxM1 →	-0.252	-3.169	.024	.019	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

ERK2 by OR1E1 expression — SKCM

Explore this box plot interactively →