OR1A1

Across TCGA patient cohorts, OR1A1 mutation is significantly associated with the RNA expression of many other genes, with 624 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR1A1-associated genes across cancer lineages are SEPTIN14P19, POTED, and C8orf89. Each is linked with OR1A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR1A1-to-partner and partner-to-OR1A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEPTIN14P19 grouped by OR1A1-low versus OR1A1-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR1A1→partner) and Y-score (partner→OR1A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SEPTIN14P19 →	+0.077	+5.288	<.001	.006	3	2
BLCA	POTED →	+0.022	+6.444	<.001	.001	3	2
UCEC	C8orf89 →	-0.297	-2.488	.008	.001	3	2
LUAD	MYF5 →	+0.339	+3.984	<.001	.001	3	2
LUAD	UGT2A3P7 →	+0.137	+3.005	<.001	.003	3	2
LUAD	RN7SKP66 →	+0.144	+3.055	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 624 associations by consensus.

SEPTIN14P19 by OR1A1 expression — BRCA

Explore this box plot interactively →