OR1A1

Across TCGA patient cohorts, OR1A1 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR1A1-associated genes across cancer lineages are eIF4E, Bcl-2, and Caspase-7-cleavedD198. Each is linked with OR1A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR1A1-to-partner and partner-to-OR1A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by OR1A1-low versus OR1A1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR1A1→partner) and Y-score (partner→OR1A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	eIF4E →	+0.230	+3.807	.003	<.001	3	2
UCEC	Bcl-2 →	-0.387	-3.302	.004	.010	3	2
UCEC	Caspase-7-cleavedD198 →	+0.626	+1.894	.007	.030	3	2
UCEC	HER3 →	+0.416	+2.183	<.001	.033	3	1
UCEC	MEK1 →	+0.457	+2.000	.001	.010	3	1
UCEC	MIG-6 →	+0.090	+1.598	.021	.022	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

eIF4E by OR1A1 expression — SKCM

Explore this box plot interactively →