OR1A1

Across TCGA cell cohorts, OR1A1 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OR1A1-associated genes across cancer lineages are OR51T1, GSG1L2, and KRTAP5-6. Each is linked with OR1A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR1A1-to-partner and partner-to-OR1A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR51T1 grouped by OR1A1-low versus OR1A1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR1A1→partner) and Y-score (partner→OR1A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR51T1 →	+0.071	+4.922	<.001	.009	3	1
BLOOD_Leukemia	GSG1L2 →	+0.058	+5.969	<.001	.001	3	1
OVARY	KRTAP5-6 →	+0.127	+3.700	.001	.008	3	1
LARGE_INTESTINE	CPLX4 →	+0.027	+3.766	<.001	.004	3	1
LARGE_INTESTINE	RIPPLY2 →	+0.470	+3.196	<.001	.007	3	1
LARGE_INTESTINE	PRAMEF20 →	+0.010	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

OR51T1 by OR1A1 expression — BLOOD_Leukemia

Explore this box plot interactively →