OR14C36

Across TCGA patient cohorts, OR14C36 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR14C36-associated genes across cancer lineages are MYH11, PKC-delta_pS664, and Cyclin-E2. Each is linked with OR14C36 in more than 2 cancer types. Because this analysis shows association rather than direction, both OR14C36-to-partner and partner-to-OR14C36 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYH11 grouped by OR14C36-low versus OR14C36-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR14C36→partner) and Y-score (partner→OR14C36) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MYH11 →	-1.010	-2.990	.039	.036	3	2
LUAD	PKC-delta_pS664 →	-0.173	-3.305	.002	.010	3	2
LUAD	Cyclin-E2 →	+0.284	+3.016	<.001	.018	3	2
SKCM	Caveolin-1 →	-0.602	-3.169	.021	.017	3	2
UCEC	4E-BP1 →	+0.397	+2.837	<.001	.001	2	3
LUSC	IRS1 →	+0.144	+3.009	.011	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

MYH11 by OR14C36 expression — LUSC

Explore this box plot interactively →