OR12D3

Across TCGA patient cohorts, OR12D3 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR12D3-associated genes across cancer lineages are p62 Lck ligand, ATM, and FASN. Each is linked with OR12D3 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR12D3-to-partner and partner-to-OR12D3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by OR12D3-low versus OR12D3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR12D3→partner) and Y-score (partner→OR12D3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.351	+3.009	.031	.019	3	2
UCEC	ATM →	-0.690	-3.169	.002	.019	3	2
UCEC	FASN →	+0.459	+3.000	.020	.036	3	1
UCEC	FoxM1 →	+0.316	+3.009	.015	.019	3	1
UCEC	Notch1 →	+0.216	+3.013	.002	.018	3	1
UCEC	Annexin-1 →	+0.682	+3.019	.009	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

p62 Lck ligand by OR12D3 expression — UCEC

Explore this box plot interactively →