Across TCGA pan-cancer cohorts, OR12D3 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of OR12D3’s most consistent transcriptional readouts.
The strongest signal is observed in thyroid carcinoma (THCA), where OR12D3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types OR12D3 is over-expressed in tumor.
THCA are the cancer types where OR12D3 tumor–normal differential expression is most reproducible.