OR12D2

Across TCGA patient cohorts, OR12D2 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR12D2-associated genes across cancer lineages are eEF2, mTOR_pS2448, and NF-kB-p65_pS536. Each is linked with OR12D2 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR12D2-to-partner and partner-to-OR12D2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by OR12D2-low versus OR12D2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR12D2→partner) and Y-score (partner→OR12D2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.343	+2.999	.020	.035	3	2
UCEC	mTOR_pS2448 →	-0.199	-3.565	.001	.002	3	2
UCEC	NF-kB-p65_pS536 →	-0.477	-3.321	.011	.009	3	2
UCEC	ATM →	-0.650	-2.321	<.001	.006	3	2
UCEC	Bax →	+0.290	+2.321	.003	.006	3	2
COAD	Caspase-7-cleavedD198 →	+0.952	+3.008	.020	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

eEF2 by OR12D2 expression — UCEC

Explore this box plot interactively →