Across TCGA pan-cancer cohorts, OR12D1 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of OR12D1’s most consistent transcriptional readouts.
The strongest signal is observed in cholangiocarcinoma (CHOL), where OR12D1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types OR12D1 is over-expressed in tumor.
CHOL are the cancer types where OR12D1 tumor–normal differential expression is most reproducible.