OR11H6

Across TCGA cell cohorts, OR11H6 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible OR11H6-associated genes across cancer lineages are HMHB1, GSG1L2, and H4C12. Each is linked with OR11H6 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR11H6-to-partner and partner-to-OR11H6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HMHB1 grouped by OR11H6-low versus OR11H6-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR11H6→partner) and Y-score (partner→OR11H6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	HMHB1 →	+2.064	+3.619	.007	.007	3	1
BLOOD_Leukemia	GSG1L2 →	+0.054	+4.969	<.001	<.001	3	1
LUNG_SCLC	H4C12 →	+0.689	+4.523	<.001	.003	3	1
SKIN	GML →	+0.029	+4.273	.005	.006	3	1
SKIN	PRORY →	+0.986	+4.273	<.001	.006	3	1
SKIN	MBD3L5 →	+0.024	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

HMHB1 by OR11H6 expression — BLOOD_Leukemia

Explore this box plot interactively →