OR10K2

Across TCGA patient cohorts, OR10K2 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR10K2-associated genes across cancer lineages are HSP70, Notch1, and eEF2. Each is linked with OR10K2 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR10K2-to-partner and partner-to-OR10K2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HSP70 grouped by OR10K2-low versus OR10K2-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR10K2→partner) and Y-score (partner→OR10K2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	HSP70 →	-0.523	-3.691	.009	.001	3	2
UCEC	Notch1 →	+0.163	+3.009	.010	.019	3	2
LUSC	eEF2 →	+0.207	+1.883	.007	.031	3	1
LUSC	GAPDH →	+0.737	+1.883	.008	.031	3	1
LUSC	PI3K-p110-a →	+0.189	+2.594	.039	.006	3	1
UCEC	JNK_pT183_Y185 →	-0.159	-2.999	.036	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

HSP70 by OR10K2 expression — LUSC

Explore this box plot interactively →