OR10K2

Across TCGA pan-cancer cohorts, OR10K2 RNA is linked to patient survival in 8 of 34 cancer types, making it the most broadly survival-associated OR10K2 data layer compared with 7 for mutation status.

The strongest signal is observed in small cell lung cancer (SCLC), where higher OR10K2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated OR10K2 expression acts as an unfavorable survival marker, although some lineages such as KIRP and THYM show a favorable association.

SCLC, SKCM, and KIRP are the cancer types where OR10K2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	DFS	Tertile	All	0.274	0.844	.001	72	view →
SKCM	DFS	Tertile	All	0.270	0.614	.027	33	view →
KIRP	DFS	Tertile	All	1.000	0.661	.010	30	view →
LIHC	OS	Tertile	III,IV	0.195	0.648	.013	27	view →
THYM	DFS	Tertile	All	0.913	0.646	.011	15	view →
KIRC	DFS	Tertile	IV	0.321	0.635	.007	12	view →
STAD	OS	Tertile	All	0.381	0.574	.048	9	view →
GBM	DFS	Tertile	All	0.526	0.191	.031	6	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

OR10K2–SCLC (DFS)

Open the SCLC breakdown →