OR10K2

Across TCGA cell cohorts, OR10K2 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible OR10K2-associated genes across cancer lineages are MAGEB5, HSF5, and OR2L5. Each is linked with OR10K2 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR10K2-to-partner and partner-to-OR10K2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB5 grouped by OR10K2-low versus OR10K2-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR10K2→partner) and Y-score (partner→OR10K2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	MAGEB5 →	+0.033	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUAD	HSF5 →	+0.009	+3.977	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR2L5 →	+0.009	+4.472	.002	.001	3	1
LUNG_NSCLC_LUAD	MGAT4D →	+0.012	+5.362	.001	<.001	3	1
BLOOD_Leukemia	NDP →	+0.035	+3.855	<.001	.007	3	1
BLOOD_Leukemia	CYP39A1 →	+0.205	+3.769	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

MAGEB5 by OR10K2 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →