OR10G4

Across TCGA patient cohorts, OR10G4 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR10G4-associated genes across cancer lineages are Src_pY527, Notch1, and p38-MAPK_pT180_Y182. Each is linked with OR10G4 in more than 2 cancer types. Because this analysis shows association rather than direction, both OR10G4-to-partner and partner-to-OR10G4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Src_pY527 grouped by OR10G4-low versus OR10G4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR10G4→partner) and Y-score (partner→OR10G4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Src_pY527 →	-0.555	-3.459	<.001	.005	3	3
UCEC	Notch1 →	+0.271	+2.713	<.001	.003	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.537	-3.700	.002	.001	3	2
UCEC	VHL →	-0.866	-2.000	.001	.010	3	2
UCEC	ASNS →	+0.391	+1.874	.005	.049	3	2
SKCM	53BP1 →	+0.347	+2.000	.038	.031	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

Src_pY527 by OR10G4 expression — UCEC

Explore this box plot interactively →