Across TCGA pan-cancer cohorts, OR10A6 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of OR10A6’s most consistent transcriptional readouts.
The strongest signal is observed in breast invasive carcinoma (BRCA), where OR10A6 RNA is repressed in tumor relative to normal tissue. In most cancer types OR10A6 is over-expressed in tumor, although a few such as BRCA and KIRC show the opposite, repressed pattern.
BRCA and KIRC are the cancer types where OR10A6 tumor–normal differential expression is most reproducible.