OR10A2

Across TCGA patient cohorts, OR10A2 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR10A2-associated genes across cancer lineages are p16_INK4a, YAP, and FASN. Each is linked with OR10A2 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR10A2-to-partner and partner-to-OR10A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p16_INK4a grouped by OR10A2-low versus OR10A2-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR10A2→partner) and Y-score (partner→OR10A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	p16_INK4a →	+0.423	+2.820	.008	.035	3	1
LUAD	YAP →	+0.300	+2.819	.015	.035	3	1
UCEC	FASN →	+0.488	+3.169	.013	.019	3	1
UCEC	ACC_pS79 →	+0.443	+3.009	.010	.019	3	1
UCEC	FOXO3a →	-0.137	-3.140	.007	.019	3	1
UCEC	PAI-1 →	+0.513	+2.321	.002	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

p16_INK4a by OR10A2 expression — LUAD

Explore this box plot interactively →