Across TCGA patient cohorts, OPTC mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OPTC-associated genes across cancer lineages are TFRC, VHL, and 4E-BP1. Each is linked with OPTC in more than 1 cancer types. Because this analysis shows association rather than direction, both OPTC-to-partner and partner-to-OPTC results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OPTC→partner) and Y-score (partner→OPTC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.872	+3.459	.001	.005	3	2
UCEC	VHL →	-1.511	-2.321	<.001	.033	3	2
UCEC	4E-BP1 →	+0.328	+2.321	.015	.035	3	2
UCEC	14-3-3_beta →	-0.119	-2.308	.018	.036	3	1
UCEC	EGFR_pY1068 →	-0.348	-3.000	.005	.036	3	1
UCEC	Gab2 →	+0.574	+3.169	.001	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Exploration

OPTC survival (RNA) · tumor vs normal (RNA) · all OPTC data types