Across TCGA cell cohorts, OPTC mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible OPTC-associated genes across cancer lineages are CTXN3, CCDC172, and LCE1C. Each is linked with OPTC in more than 1 cancer types. Because this analysis shows association rather than direction, both OPTC-to-partner and partner-to-OPTC results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OPTC→partner) and Y-score (partner→OPTC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CTXN3 →	+0.012	+5.201	<.001	.006	3	2
LARGE_INTESTINE	CCDC172 →	+0.006	+5.415	<.001	.004	3	1
BLOOD_Leukemia	LCE1C →	+0.432	+4.922	.002	.009	3	1
BLOOD_Leukemia	SLC5A8 →	+0.182	+5.201	<.001	.006	3	1
BLOOD_Leukemia	OR10A6 →	+0.044	+5.201	<.001	.006	3	1
BLOOD_Leukemia	CFHR2 →	+0.395	+5.539	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Exploration

OPTC survival (RNA) · tumor vs normal (RNA) · all OPTC data types