OPRPN

Across TCGA patient cohorts, OPRPN mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OPRPN-associated genes across cancer lineages are Cyclin-E2, ERK2, and Src_pY416. Each is linked with OPRPN in more than 1 cancer types. Because this analysis shows association rather than direction, both OPRPN-to-partner and partner-to-OPRPN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E2 grouped by OPRPN-low versus OPRPN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OPRPN→partner) and Y-score (partner→OPRPN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-E2 →	+0.189	+3.179	.020	.010	3	2
UCEC	ERK2 →	+0.225	+2.459	.015	.020	3	1
UCEC	Src_pY416 →	-0.242	-3.571	.038	.002	3	1
UCEC	Src_pY527 →	-0.481	-2.459	.020	.020	3	1
UCEC	STAT3_pY705 →	-0.369	-2.459	.003	.020	3	1
UCEC	Bak →	+0.319	+3.169	.008	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Cyclin-E2 by OPRPN expression — UCEC

Explore this box plot interactively →