OPRPN

Across TCGA pan-cancer cohorts, OPRPN RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of OPRPN’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where OPRPN RNA is repressed in tumor relative to normal tissue. In most cancer types OPRPN is over-expressed in tumor, although a few such as BRCA and HNSC show the opposite, repressed pattern.

BRCA, LIHC, and HNSC are the cancer types where OPRPN tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in OPRPN RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	Female	All	−3.252	<.001	8	view →
LIHC	All	All	+0.994	<.001	5	view →
HNSC	All	II,III,IV	−0.863	.003	5	view →
CHOL	Male	All	−0.888	.007	2	view →
UCEC	All	All	+0.344	.008	2	view →
PRAD	All	All	−0.262	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

OPRPN–BRCA

Open the BRCA breakdown →