Across TCGA cell cohorts, OPRPN RNA expression is significantly associated with the mutation status of many other genes, with 159 significant associations in total. URINARY_TRACT shows the largest number of these associations.

The most reproducible OPRPN-associated genes across cancer lineages are KALRN, MUC22, and ADGRE2. Each is linked with OPRPN in more than 1 cancer types. Because this analysis shows association rather than direction, both OPRPN-to-partner and partner-to-OPRPN results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OPRPN→partner) and Y-score (partner→OPRPN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	KALRN →	+5.000	+0.018	.006	.001	3	2
BREAST	MUC22 →	+3.781	+0.496	.009	.002	3	2
LUNG_SCLC	ADGRE2 →	+5.029	+0.139	.006	<.001	3	2
LUNG_NSCLC_LUAD	DNM1 →	+4.887	+0.057	.009	<.001	3	2
LUNG_NSCLC_LUAD	FOXA2 →	+4.887	+0.057	.009	<.001	3	2
LUNG_NSCLC_LUAD	SLC12A3 →	+2.887	+0.021	.009	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 159 associations by consensus.

Exploration

OPRPN survival (RNA) · tumor vs normal (RNA) · all OPRPN data types