OPRPN

Across TCGA cell cohorts, OPRPN mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible OPRPN-associated genes across cancer lineages are HTR1E and GPR33. Each is linked with OPRPN in more than 1 cancer types. Because this analysis shows association rather than direction, both OPRPN-to-partner and partner-to-OPRPN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HTR1E grouped by OPRPN-low versus OPRPN-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OPRPN→partner) and Y-score (partner→OPRPN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	HTR1E →	+0.036	+4.977	<.001	.007	3	1
SKIN	GPR33 →	+0.012	+4.977	.002	.007	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

HTR1E by OPRPN expression — SKIN

Explore this box plot interactively →