OPRPN

Across TCGA cell cohorts, OPRPN mutation is significantly associated with the mutation status of many other genes, with 604 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OPRPN-associated genes across cancer lineages are WDR62, SLC8B1, and IGF2BP2. Each is linked with OPRPN in more than 2 cancer types. Because this analysis shows association rather than direction, both OPRPN-to-partner and partner-to-OPRPN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, WDR62 grouped by OPRPN-low versus OPRPN-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OPRPN→partner) and Y-score (partner→OPRPN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	WDR62 →	+3.169	+4.548	.004	.004	1	3
LARGE_INTESTINE	SLC8B1 →	+2.865	+4.217	.007	.007	1	2
SKIN	IGF2BP2 →	+5.392	+4.824	.004	.004	1	2
LARGE_INTESTINE	ZNF596 →	+4.087	+5.044	.001	.001	1	2
LARGE_INTESTINE	GTF2IRD2B →	+5.087	+4.523	.006	.006	1	2
LARGE_INTESTINE	ZNF789 →	+5.087	+4.523	.006	.006	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 604 associations by consensus.

WDR62 by OPRPN expression — SKIN

Explore this box plot interactively →