OPRD1

Across TCGA patient cohorts, OPRD1 mutation is significantly associated with the RNA expression of many other genes, with 723 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OPRD1-associated genes across cancer lineages are RNU6-1246P, SBF1, and SRP54. Each is linked with OPRD1 in more than 2 cancer types. Because this analysis shows association rather than direction, both OPRD1-to-partner and partner-to-OPRD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1246P grouped by OPRD1-low versus OPRD1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OPRD1→partner) and Y-score (partner→OPRD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-1246P →	+0.169	+5.225	<.001	.001	3	3
UCEC	SBF1 →	+0.646	+2.243	<.001	.006	3	2
UCEC	SRP54 →	+0.524	+2.265	.006	.006	3	2
UCEC	METTL16 →	+0.554	+3.364	<.001	.004	3	2
UCEC	GZMA →	+1.156	+2.233	.001	.006	3	2
UCEC	ERFL →	+0.471	+2.906	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 723 associations by consensus.

RNU6-1246P by OPRD1 expression — SKCM

Explore this box plot interactively →