OPRD1

Across TCGA pan-cancer cohorts, OPRD1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of OPRD1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where OPRD1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types OPRD1 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

KIRP, KIRC, and BRCA are the cancer types where OPRD1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in OPRD1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	III,IV	+0.266	<.001	11	view →
KIRC	All	IV	+0.204	<.001	11	view →
BRCA	Female	All	+0.391	<.001	6	view →
UCEC	All	All	+0.164	.002	6	view →
COAD	Female	II,III,IV	+0.474	.018	4	view →
LUAD	All	All	+0.277	.001	3	view →
KICH	All	All	+0.062	.005	3	view →
BLCA	Female	III,IV	+0.061	.012	3	view →
THCA	Male	All	−0.055	.019	3	view →
PRAD	All	All	+0.144	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

OPRD1–KIRP

Open the KIRP breakdown →