OPRD1

Across TCGA cell cohorts, OPRD1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,657 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible OPRD1-associated GO terms across cancer lineages are G protein-coupled opioid receptor signaling pathway, Heterochromatin formation, and Epigenetic regulation of gene expression. Each is linked with OPRD1 in more than 7 cancer types. Because this analysis shows association rather than direction, both OPRD1-to-partner and partner-to-OPRD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, G protein-coupled opioid receptor signaling pathway grouped by OPRD1-low versus OPRD1-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (OPRD1→partner) and Y-score (partner→OPRD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	G protein-coupled opioid receptor signaling pathway →	-0.351	-1.864	<.001	.001	3	8
SOFT_TISSUE	Heterochromatin formation →	+0.086	+1.775	<.001	.001	3	8
SOFT_TISSUE	Epigenetic regulation of gene expression →	+0.073	+1.760	<.001	.001	3	7
SOFT_TISSUE	Heterochromatin organization →	+0.083	+1.628	<.001	.004	3	7
SOFT_TISSUE	Protein-DNA complex organization →	+0.080	+1.879	<.001	<.001	3	7
STOMACH	Cytoplasmic translation →	+0.085	+1.275	<.001	.008	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,657 associations by consensus.

G protein-coupled opioid receptor signaling pathway by OPRD1 expression — LUNG_SCLC

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