OPRD1

Across TCGA cell cohorts, OPRD1 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible OPRD1-associated genes across cancer lineages are GALP, KIR2DL3, and MYF6. Each is linked with OPRD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OPRD1-to-partner and partner-to-OPRD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GALP grouped by OPRD1-low versus OPRD1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OPRD1→partner) and Y-score (partner→OPRD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	GALP →	+0.019	+5.415	<.001	.004	3	1
SKIN	KIR2DL3 →	+0.006	+4.977	<.001	.007	3	1
STOMACH	MYF6 →	+0.013	+5.285	<.001	.003	3	1
LUNG_SCLC	IL3 →	+0.055	+5.029	<.001	.006	3	1
LUNG_SCLC	PRAMEF10 →	+1.180	+5.643	<.001	.002	3	1
LUNG_SCLC	PRAMEF17 →	+0.013	+5.643	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

GALP by OPRD1 expression — SKIN

Explore this box plot interactively →