OPN5

Across TCGA pan-cancer cohorts, OPN5 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated OPN5 data layer compared with 16 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher OPN5 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated OPN5 expression acts as an unfavorable survival marker.

BLCA, OV, and LGG are the cancer types where OPN5 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	All	0.244	0.721	.001	30	view →
OV	DFS	Median	All	0.132	0.541	.001	6	view →
LGG	OS	Median	All	0.332	0.830	.009	6	view →
ACC	OS	Median	All	0.118	0.624	.038	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

OPN5–BLCA (OS)

Open the BLCA breakdown →