OPN4

Across TCGA cell cohorts, OPN4 RNA expression is significantly associated with the go_rna of many other GO terms, with 98 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible OPN4-associated GO terms across cancer lineages are Positive regulation of extracellular matrix disassembly, Response to human chorionic gonadotropin, and Positive regulation of ERBB signaling pathway. Each is linked with OPN4 in more than 2 cancer types. Because this analysis shows association rather than direction, both OPN4-to-partner and partner-to-OPN4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of extracellular matrix disassembly grouped by OPN4-low versus OPN4-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (OPN4→partner) and Y-score (partner→OPN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Positive regulation of extracellular matrix disassembly →	+0.167	+0.013	<.001	.009	3	3
CNS	Response to human chorionic gonadotropin →	-0.182	-0.106	.004	.008	3	3
SKIN	Positive regulation of ERBB signaling pathway →	+0.090	+0.013	<.001	.009	3	2
SKIN	Negative regulation of integrin-mediated signaling pathway →	+0.161	+0.013	.004	.009	3	2
SKIN	Exploration behavior →	+0.108	+0.013	.006	.009	3	2
BLOOD_Lymphoma	Putrescine biosynthetic process from arginine, via ornithine →	-0.122	-0.006	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 98 associations by consensus.

Positive regulation of extracellular matrix disassembly by OPN4 expression — SKIN

Explore this box plot interactively →