OPN4

Across TCGA cell cohorts, OPN4 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible OPN4-associated genes across cancer lineages are PPIAL4E, TSHB, and OR8B4. Each is linked with OPN4 in more than 1 cancer types. Because this analysis shows association rather than direction, both OPN4-to-partner and partner-to-OPN4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPIAL4E grouped by OPN4-low versus OPN4-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OPN4→partner) and Y-score (partner→OPN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PPIAL4E →	+0.056	+4.347	<.001	.001	3	1
LUNG_NSCLC_LUAD	TSHB →	+0.055	+3.189	<.001	.007	3	1
LUNG_NSCLC_LUAD	OR8B4 →	+0.019	+3.472	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

PPIAL4E by OPN4 expression — SKIN

Explore this box plot interactively →