OPN1MW

Across TCGA patient cohorts, OPN1MW mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OPN1MW-associated genes across cancer lineages are EGFR, JNK2, and p70-S6K. Each is linked with OPN1MW in more than 1 cancer types. Because this analysis shows association rather than direction, both OPN1MW-to-partner and partner-to-OPN1MW results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR grouped by OPN1MW-low versus OPN1MW-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OPN1MW→partner) and Y-score (partner→OPN1MW) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR →	-0.184	-3.169	.036	.020	3	1
UCEC	JNK2 →	+0.229	+3.169	.036	.020	3	1
UCEC	p70-S6K →	+0.244	+3.196	.021	.010	3	1
UCEC	Tuberin →	+0.381	+2.817	.009	.036	3	1
UCEC	ASNS →	+0.498	+3.000	.012	.036	3	1
UCEC	YB-1_pS102 →	-0.280	-3.169	.005	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

EGFR by OPN1MW expression — UCEC

Explore this box plot interactively →