OPN1LW

Across TCGA pan-cancer cohorts, OPN1LW Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated OPN1LW data layer compared with 13 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher OPN1LW Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated OPN1LW expression acts as an unfavorable survival marker.

LUSC, LGG, and UCEC are the cancer types where OPN1LW Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Median	All	0.245	0.765	<.001	24	view →
LGG	OS	Median	All	0.250	0.830	.001	12	view →
UCEC	OS	Median	IV	0.133	0.754	<.001	12	view →
LUAD	DFS	Median	All	0.333	0.678	.038	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

OPN1LW–LUSC (OS)

Open the LUSC breakdown →