OPHN1

Across TCGA pan-cancer cohorts, OPHN1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated OPHN1 data layer compared with 25 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher OPHN1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated OPHN1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

UCEC, CCRCC, and PDAC are the cancer types where OPHN1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	III,IV	0.433	1.000	.007	32	view →
CCRCC	OS	Median	All	0.985	0.900	.020	10	view →
PDAC	OS	Tertile	III,IV	0.867	0.334	.009	9	view →
LSCC	OS	Quartile	All	0.916	0.815	.012	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

OPHN1–UCEC (OS)

Open the UCEC breakdown →