OPHN1

Across TCGA pan-cancer cohorts, OPHN1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of OPHN1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where OPHN1 RNA is repressed in tumor relative to normal tissue. In most cancer types OPHN1 is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, THCA, and LIHC are the cancer types where OPHN1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in OPHN1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−1.344	<.001	12	view →
THCA	Male	III,IV	−1.408	<.001	9	view →
LIHC	Female	II,III,IV	+0.595	<.001	7	view →
KICH	Female	All	−1.416	<.001	6	view →
BRCA	All	III,IV	−0.540	<.001	6	view →
HNSC	All	III,IV	+0.434	.010	6	view →
CHOL	All	All	+1.035	<.001	5	view →
LUSC	Male	All	−0.705	<.001	5	view →
KIRP	Male	All	−0.985	<.001	4	view →
UCEC	All	All	−0.662	.013	2	view →
STAD	Female	All	−0.535	.015	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

OPHN1–KIRC

Open the KIRC breakdown →