OPHN1

Across TCGA patient cohorts, OPHN1 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OPHN1-associated genes across cancer lineages are PCNA, 14-3-3_beta, and JNK2. Each is linked with OPHN1 in more than 2 cancer types. Because this analysis shows association rather than direction, both OPHN1-to-partner and partner-to-OPHN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by OPHN1-low versus OPHN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OPHN1→partner) and Y-score (partner→OPHN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.184	+2.169	.006	<.001	3	3
UCEC	14-3-3_beta →	-0.093	-1.973	.002	.008	3	2
UCEC	JNK2 →	+0.158	+1.893	.010	<.001	3	2
UCEC	MEK1 →	+0.331	+1.893	.003	<.001	3	2
UCEC	ASNS →	+0.372	+1.847	<.001	.007	3	2
UCEC	Caspase-7-cleavedD198 →	+0.575	+1.785	.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

PCNA by OPHN1 expression — UCEC

Explore this box plot interactively →