OPHN1

Across TCGA cell cohorts, OPHN1 mutation is significantly associated with the RNA expression of many other genes, with 36 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible OPHN1-associated genes across cancer lineages are REG1B, OC90, and CEACAM4. Each is linked with OPHN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OPHN1-to-partner and partner-to-OPHN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, REG1B grouped by OPHN1-low versus OPHN1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OPHN1→partner) and Y-score (partner→OPHN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	REG1B →	+2.209	+2.518	<.001	.006	3	2
LUNG_NSCLC_LUAD	OC90 →	+0.007	+2.786	<.001	.007	3	2
BLOOD_Lymphoma	CEACAM4 →	+0.027	+3.342	.001	.008	3	1
BLOOD_Lymphoma	OR10K1 →	+0.008	+3.867	<.001	.002	3	1
BLOOD_Lymphoma	VN1R3 →	+0.011	+4.247	<.001	.004	3	1
BLOOD_Lymphoma	IFNA17 →	+0.010	+4.247	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

REG1B by OPHN1 expression — LARGE_INTESTINE

Explore this box plot interactively →