OPCML-IT1

Across TCGA pan-cancer cohorts, OPCML-IT1 RNA is linked to patient survival in 8 of 34 cancer types, making it the most broadly survival-associated OPCML-IT1 data layer.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher OPCML-IT1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated OPCML-IT1 expression acts as an unfavorable survival marker, although some lineages such as LGG and STAD show a favorable association.

OV, LGG, and LAML are the cancer types where OPCML-IT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	DFS	Quartile	IV	0.196	0.525	<.001	24	view →
LGG	OS	Tertile	All	0.576	0.371	.001	23	view →
LAML	DFS	Tertile	All	0.410	0.597	.038	18	view →
STAD	OS	Tertile	III,IV	0.484	0.331	.018	12	view →
DLBC	DFS	Tertile	III,IV	0.067	0.712	.016	9	view →
SARC	DFS	Tertile	All	0.874	0.599	.037	9	view →
THCA	OS	Tertile	All	0.994	0.914	.019	8	view →
LIHC	OS	Tertile	All	0.281	0.500	.020	6	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

OPCML-IT1–OV (DFS)

Open the OV breakdown →