OPCML-IT1

Across TCGA pan-cancer cohorts, OPCML-IT1 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of OPCML-IT1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where OPCML-IT1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types OPCML-IT1 is over-expressed in tumor, although a few such as PRAD and LUSC show the opposite, repressed pattern.

THCA, PRAD, and KICH are the cancer types where OPCML-IT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in OPCML-IT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	All	+0.075	.014	2	view →
PRAD	All	All	−0.018	<.001	2	view →
KICH	Female	All	+0.010	.032	1	view →
LUSC	Female	All	−0.007	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

OPCML-IT1–THCA

Open the THCA breakdown →