OPA3

Across TCGA pan-cancer cohorts, OPA3 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated OPA3 data layer compared with 22 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher OPA3 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated OPA3 expression acts as an unfavorable survival marker.

ESCA, KICH, and BLCA are the cancer types where OPA3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	DFS	Median	All	0.091	0.536	<.001	18	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
BLCA	OS	Median	All	0.188	0.687	.020	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

OPA3–ESCA (DFS)

Open the ESCA breakdown →