OPA3

Across TCGA pan-cancer cohorts, OPA3 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of OPA3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where OPA3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types OPA3 is over-expressed in tumor, although a few such as THCA and KIRP show the opposite, repressed pattern.

HNSC, LIHC, and THCA are the cancer types where OPA3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in OPA3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+0.781	<.001	12	view →
LIHC	Female	II,III,IV	+1.354	<.001	9	view →
THCA	Male	III,IV	−0.712	<.001	9	view →
CHOL	All	All	+1.556	<.001	5	view →
STAD	All	II,III,IV	+0.539	.001	4	view →
LUSC	All	III,IV	+0.788	.038	2	view →
KIRP	Male	All	−0.382	.003	2	view →
LUAD	All	All	−0.201	.018	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

OPA3–HNSC

Open the HNSC breakdown →