OPA3

Across TCGA pan-cancer cohorts, OPA3 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated OPA3 data layer compared with 22 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher OPA3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated OPA3 expression acts as an unfavorable survival marker.

CCRCC, LSCC, and UCEC are the cancer types where OPA3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.615	0.867	.004	20	view →
LSCC	DFS	Tertile	All	0.580	0.825	.007	14	view →
UCEC	DFS	Quartile	II,III,IV	0.485	1.000	.030	4	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

OPA3–CCRCC (DFS)

Open the CCRCC breakdown →