OPA3

Across TCGA patient cohorts, OPA3 mutation is significantly associated with the RNA expression of many other genes, with 424 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OPA3-associated genes across cancer lineages are RN7SL177P, LINC02722, and COX6A1P3. Each is linked with OPA3 in more than 1 cancer types. Because this analysis shows association rather than direction, both OPA3-to-partner and partner-to-OPA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL177P grouped by OPA3-low versus OPA3-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OPA3→partner) and Y-score (partner→OPA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RN7SL177P →	+0.144	+5.147	.002	.003	3	2
BLCA	LINC02722 →	+0.115	+5.147	<.001	.003	3	2
HNSC	COX6A1P3 →	+0.121	+5.368	<.001	.005	3	1
HNSC	RBMY2EP →	+1.004	+5.303	<.001	.006	3	1
COAD	MAGED4 →	+0.029	+4.577	<.001	.004	3	1
BLCA	OR52B4 →	+0.050	+4.788	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 424 associations by consensus.

RN7SL177P by OPA3 expression — BLCA

Explore this box plot interactively →