OPA3

Across TCGA patient cohorts, OPA3 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OPA3-associated genes across cancer lineages are FOXO3a_pS318_S321, Notch1, and PCNA. Each is linked with OPA3 in more than 1 cancer types. Because this analysis shows association rather than direction, both OPA3-to-partner and partner-to-OPA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by OPA3-low versus OPA3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OPA3→partner) and Y-score (partner→OPA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.142	-3.160	.029	.019	3	1
UCEC	Notch1 →	+0.277	+3.183	<.001	.009	3	1
UCEC	PCNA →	+0.237	+2.999	.036	.035	3	1
UCEC	AMPK_alpha →	+0.230	+3.000	.021	.036	3	1
UCEC	Annexin-1 →	+0.782	+3.019	.004	.019	3	1
UCEC	STAT3_pY705 →	-0.523	-3.321	<.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

FOXO3a_pS318_S321 by OPA3 expression — UCEC

Explore this box plot interactively →