Across TCGA pan-cancer cohorts, OPA1-AS1 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated OPA1-AS1 data layer.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher OPA1-AS1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated OPA1-AS1 expression acts as an unfavorable survival marker, although some lineages such as UCS and SKCM show a favorable association.

UCS, ACC, and OV are the cancer types where OPA1-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	DFS	Median	IV	0.952	0.367	.001	36	view →
ACC	DFS	Median	All	0.510	0.789	.001	32	view →
OV	OS	Quartile	All	0.803	0.890	.006	22	view →
BLCA	DFS	Median	All	0.176	0.503	.003	18	view →
THCA	OS	Median	III,IV	0.876	0.978	.002	17	view →
SKCM	OS	Quartile	III,IV	0.529	0.215	.004	16	view →
KIRC	DFS	Median	III,IV	0.336	0.564	.015	15	view →
HNSC	DFS	Median	IV	0.703	0.580	.014	12	view →
CHOL	DFS	Median	IV	0.251	0.794	.010	12	view →
LIHC	DFS	Median	III,IV	0.587	0.274	.002	11	view →
LUSC	OS	Median	II,III,IV	0.799	0.655	.008	8	view →
KIRP	OS	Tertile	II,III,IV	0.848	0.598	.014	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

Exploration

Same gene, other analysis: OPA1-AS1 tumor-vs-normal RNA expression · all OPA1-AS1 data types